Leonard Nimoy

Himself

Louie

Hugh Hefner

Candace, Hannah Horvath

Fat Tony, Fit Tony

Kara DioGuardi

Linda McCartney

Judd Apatow

Martha Stewart

Milhouse Van Houten, Jimbo Jones, Rod Flanders, Janey Powell, Sarah Wiggum, Additional Voices, Janey, Others, Boy, Dolph...

Prime Minister, Severus Snape

Leon Kompowsky

Virgil

Professor John Frink, Sr.

Francesca

Ned Flanders, Principal Skinner, Lenny, Kent Brockman, Dr. Hibbert, Mr. Burns, Waylon Smithers, Otto, Montgomery Burns, Reverend Lovejoy...

Dana Scully

Marge Simpson, Patty Bouvier, Selma Bouvier, Jacqueline Bouvier, Others, Jackie Bouvier, Actress as Marge, Angela Lansburry, Audience, Aunt Gladys...

Hugh St. John Alastair Parkfield

Ellen DeGeneres

The Great Raymondo

Santa's Little Helper, Snowball II, African Animals, Baboons, Badger, Barnyard Animals, Buffalo, Cougar, Dolphins, Executive Vice-President...

Himself

Herb Powell

Rupert Murdoch

Henry, Simon Cowell

Herself

Happy Little Elf, Rubber Baby Buggy Bumper Babysitting Service Receptionist

Charles Heathbar, Ricky Gervais

Lady Gaga